Titanium Reagents in Heterocyclic Synthesis

Enaminonitriles in Heterocyclic Synthesis:

Benzylcyanide and 4-nitrobenzylcyanide condensed with triethyl orthoformate and piperidine or morpholine to yield 2-aryl-2-piperidinyl or 2-morpholinylacrylonitriles. These coupled with aromatic diazonium salts to yield the 2-arylhydrazno-2-arylethane nitriles in good yields. The latter were converted into 4-aminopyrazoles in good yields using the Thorpe-Ziegler cyclization.

Reaction Between Grignard Reagents and Heterocyclic N-oxides Synthesis of Substituted Pyridines, Piperidines and Piperazines

Acid hydrazides, potent reagents for synthesis of oxygen-, nitrogen-, and/or sulfur-containing heterocyclic rings.

Nitrogen‐, and/or Sulfur-Containing Heterocyclic Rings Poulomi Majumdar,†,‡ Anita Pati,†,§ Manabendra Patra, Rajani Kanta Behera,† and Ajaya Kumar Behera*,† †Organic Synthesis Laboratory, School of Chemistry, Sambalpur University, Jyoti Vihar, Burla 768019, Orissa, India ‡State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian, 116024, P.R...

Functionalization of heterocyclic compounds using polyfunctional magnesium and zinc reagents

In this review we summarize the most important procedures for the preparation of functionalized organzinc and organomagnesium reagents. In addition, new methods for the preparation of polyfunctional aryl- and heteroaryl zinc- and magnesium compounds, as well as new Pd-catalyzed cross-coupling reactions, are reported herein. Experimental details are given for the most important reactions in the ...

Copper N-heterocyclic carbene (NHC) complexes as carbene transfer reagents.

A method is described that makes use of easily prepared, inexpensive copper synthons as N-heterocyclic carbene (NHC) transfer agents to generate catalytically relevant gold and palladium complexes.